WELCOME TO THE FOUR-DIMENSIONAL (4D) MODELLING OF DISEASE PATTERNS WEBSITE!
 View the Discovery Channel Daily Planet clip on the Virtual Caveman here.
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The 4D Project capitalizes on existing Canadian strengths and expertise from the Project Leader Dr. Christoph W. Sensen, who is renowned for his work in bioinformatics and the four co-investigators who are each prominent leaders in their fields.

The Project is organized into five components, four of which are separate biomedical case studies with their own research objectives. These four components serve as sources of experimental data and user expertise. The fifth component is led by Dr. Sensen's team and combines the knowledge gained from these four components into a unified 4D system for data analysis and visualization. The system is therefore capable of handling diverse case studies, as well as being generic and extendible to new research scenarios.

Dr. Sensen’s team at the University of Calgary is working on integrating complex genomic data sets into coherent visual models so resulting information can be visualized in intuitive ways.

Dr. Hallgrimsson's team at the University of Calgary is using the 4D system to investigate craniofacial development in mice.

Dr. Robertson's team at Dalhousie University is exploring the relationship between genetic processes and patient responsiveness to Multiple Sclerosis drug therapy.

Dr. Wishart's team at the University of Alberta is integrating the study of metabolomics by supplying in-vivo and in-vitro metabolmic data of mice and rats to the 4D system.

Dr. Shearer's team at the University of Calgary uses the 4D system to study obesity, a complex polygenetic condition.

 

 

This project is supported by Genome Alberta and Genome Canada. Genome Canada is a private, non-profit corporation whose mandate is to develop and implement a national strategy in genomics and proteomics research for the benefit of all Canadians.